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Home - Products - Cell Cycle/DNA Damage - Potassium Channel - UK 78282 hydrochloride

UK 78282 hydrochloride

CAS No. 136647-02-4

UK 78282 hydrochloride( —— )

Catalog No. M33944 CAS No. 136647-02-4

UK 78282 hydrochloride, a novel potent and selective Kv1.3 blocker.UK 78282 hydrochloride inhibits Kv1.3 voltage-gated potassium channels and suppresses human T cell activation.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 128 Get Quote
5MG 188 Get Quote
10MG 330 Get Quote
25MG 532 Get Quote
50MG 759 Get Quote
100MG 981 Get Quote
500MG 2007 Get Quote
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Biological Information

  • Product Name
    UK 78282 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    UK 78282 hydrochloride, a novel potent and selective Kv1.3 blocker.UK 78282 hydrochloride inhibits Kv1.3 voltage-gated potassium channels and suppresses human T cell activation.
  • Description
    UK-78282, a novel piperidine, potent and selective Kv1.3 blocker with an IC50 of 200 nM. UK-78,282 effectively suppresses human T-lymphocyte activation in vitro. UK-78,282 binds to residues at the inner surface of the channel overlapping the site of action of verapamil.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Potassium Channel
  • Recptor
    Potassium Channel
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    136647-02-4
  • Formula Weight
    466.05
  • Molecular Formula
    C29H36ClNO2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (214.57 mM; Ultrasonic )
  • SMILES
    Cl.COc1ccc(CCCN2CCC(COC(c3ccccc3)c3ccccc3)CC2)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. D C Hanson, et al. UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation. Br J Pharmacol. 1999 Apr;126(8):1707-16?
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